Wigan Athletic will keen to erase the memory of last weekend's drubbing by Blackpool but face a massive task in halting red-hot Chelsea at the DW Stadium.
The Latics were stunned 4-0 by the newly-promoted side last Saturday while Chelsea proved they are in no mood to relinquish their grip on the title with a 6-0 thrashing of West Brom.
Wigan played Chelsea on the final day of last season and few have forgotten how the Lancashire side suffered a humiliating 8-0 defeat when Carlo Ancelotti's side clinched the title.
However, Wigan were one of the few teams to inflict a league defeat on Chelsea last season with goals from Titus Bramble, Hugo Rodallega and Paul Scharner giving Roberto Martinez's men a 3-1 success.
If recent form is anything to go by then Chelsea will run out easy winners. Wigan have shipped 24 goals in their last 10 league games while the Blues have gone 406 minutes without conceding at the back.
Wigan news
Charles N'Zogbia could return to the Wigan side for the visit of the champions after being left out against the Seasiders.
The French winger was omitted for last week's 4-0 thrashing by manager Martinez, who questioned the player's attitude amid speculation over his future.
Martinez has since played down reports of a rift between the pair and said the 24-year-old will be in contention on Saturday.
The Spanish boss must also decide whether to keep faith with goalkeeper Chris Kirkland after his personal horror show in their season opener.
Forward Victor Moses has been ruled out with a calf injury while club captain Gary Caldwell remains on the sidelines after double hip surgery in the summer.
Chelsea news
Chelsea boss Ancelotti may give a Premier League debut to new signing Ramires. The Brazil international has joined from Benfica, although Jon Obi Mikel performed well against the Baggies.
Didier Drogba, who is aiming to score a league hat-trick for the third consecutive game, is sure to retain his place up front and he will be supported by Frenchman Nicolas Anelka.
Branislav Ivanovic is expected to be recalled into Ancelotti's starting XI after missing out last week due to an injury sustained on international duty. Portuguese full-back Paulo Ferreira will make way.
Jose Bosingwa remains on the sidelines with a knee injury and will play no part as Chelsea look to maintain their impressive start to the new campaign.
Possible starting XIs:
Wigan: Kirkland, Boyce, Alcaraz, Gohouri, Figueroa, McCarthy, Diame, Moses, Watson, Rodallega, Boselli.
Chelsea: Cech, Ivanovic, Terry, Alex, Cole, Mikel, Essien, Lampard, Malouda, Anelka, Drogba.